1. L-citrulline is an amino acid normally made by the body. In the body, L-citrulline is converted to L-arginine, another type of amino acid.
L-arginine improves blood flow. It does so by creating nitric oxide (NO), a compound that helps widen blood vessels. L-arginine has been shown to help people with heart disease or clogged arteries because of its vessel-widening abilities.
2. Arginine: Good for the Heart
The same effect on blood vessels helps ease symptoms of erectile dysfunction (ED). The L-citrulline to NO path increases blood flow to a man’s genitals. In one study, this increase in blood flow appeared to decrease symptoms of mild ED and improve the ability to maintain an erection. No studies have examined the use of L-citrulline in moderate to severe cases of ED.
3. Norvaline is a form of the Branched Chain Amino Acid L-Valine, but aside from L-Valine's normal benefits, L-Norvaline has been shown to positively effect circulation and nitric oxide production. The difference, and reason for the the “nor” prefix only makes note that Norvaline is one hydrogen molecule longer than the original protein Valine. In the body, as with everything else in life, for every action there is an equal and opposite reaction. This is one fatal issue with nitric oxide production in the body. When nitric oxide is produced in our bodies, we are simultaneously producing enzymes to inhibit and thus restrict that production. The presence of L-Norvaline will actually inhibit your body from inhibiting your nitric oxide production, thus resulting in heightened muscle pumps and nutrient transportation during and after exercise. It has also been shown to be active during tissue regeneration as well as overall muscle growth. In studies done by the Department of Medical Physiology and Microcirculation at Texas A&M University Norvaline has been shown to increase nitric oxide production by 55%.
4. Agmatine Sulfate is a biogenic amine that is derived from the amino acid L-Arginine. This occurs due to a process called decarboxylation, which is the removal of a carboxylic acid group from the amino acid.
The resulting compound, Agmatine Sulfate, appears to be stored within the neurons of the brain and is released as these neurons become activated.
Due to this interesting process and storage mechanism, Agmatine Sulfate has actions and activities that are very different from its predecessor. It also appears to be a promising supplement in terms of neuropathic pain, drug addiction, stroke protection, and even general cognitive health. It is also considered to be a novel neurotransmitter, or at the very least a neuromodulator.
The primary method of action for Agmatine Sulfate is by crossing the blood-brain barrier, entering into the central nervous system, and then binding to NMDA Glutamate receptors.
Since this is the chief neurotransmitter involved in synaptic plasticity and memory function, this may be responsible for a number of the associated cognitive benefits of this supplement.
The supplement also appears to help regulate the levels of Nitric Oxide. This is especially true in cases where this chemical has been improperly elevated. It also inhibits, or blocks, calcium channels.
Agmatine Sulfate also has some analgesic activities, releasing a number of opioid and endorphin chemicals, seeming to have some sort of synergistic effect on many of these chemicals.
It is also capable of enhancing the effects of both morphine and fentanyl to increase pain killing, reduce tolerance, and lower addiction. It even appears to work in synergy with marijuana.
There are a number of benefits associated with this supplement. In fact, it appears to do much of the same things as Arginine but at a greater rate of potency. It has a decidedly Nootropic effect and can help people achieve a mental edge, whether in or out of the gym or athletic training.
The supplement supports a healthy mood, has anti-anxiety properties, and may also stack very well with other Nootropic supplements like Aniracetam and other Ampakines.
Agmatine Sulfate also acts as an anti-oxidant. Part of this benefit is due to the fact that it helps to limit the activity of Glutamate and thus, over excitation of the brain. Many people will take Agmantine Sulfate to prevent excitotoxicity which can occur when using too much Sunifiram, Unifiram, Modafinil or other similar nootropic supplements. Removal of free radicals, toxins, and other poisons can help to keep not only the brain but the entire body in a better state of health.
There are also a number of athletic effects. This includes enhancing and improving insulin response of the body. This has long been thought to be one of the biggest keys to building a leaner, harder, and more muscular body.
The supplement is additionally thought to stimulate the production and increase of GH and LH hormones which can also have positive effects upon overall body composition. Due to the regulation of Nitric Oxide levels in the body, Agmatine Sulfate may also lead to better muscle “pumps” in weight training athletes.
Another key benefit is that this supplement seems to act as an analgesic. This can be very beneficial for the relief of pain. Agmatine is observed to release several types of endorphins and natural opioid substances in the brain. It has also been used in conjunction with morphine and marijuana, having a synergistic effect. Some researchers feel that there may be therapeutic uses for Agmatine in helping to treat addictions.
5. Given that there are many different types of glycerols, its been found that GMS is far superior for bodybuilding applications. Typical GMS on the market is made up of very large particles that have a lot of trouble dissolving and cause some difficulty in consumption, while a micronized form of GMS will maximize its mixability.
Glycerol is a substance which has been shown to elevate blood plasma volume. Recent studies have shown that consuming glycerol before a workout can boost your ability to retain intra-muscular fluid by up to fifty percent. Hyperhydration in elite endurance athletes has been well documented and proven effective
6. Niacin primarily used to treat hypercholesterolemia and pellagra (niacin deficiency). Insufficient niacin in the diet can cause nausea, skin and mouth lesions, anemia, headaches, and tiredness.
Immediately after you have consumed an overdose of niacin, you will become more vascular. Vascularity is one of the few details that make the difference during bodybuilding contests. Regular niacin flushing also stimulated the production of growth hormone. Growth hormone is very important for building more muscle and gaining strength.
7. Magnesium gluconate is a salt of magnesium and gluconic acid. Taken as a supplement, it is used to supply adequate amounts of the essential element, magnesium.
Dietary magnesium is required by every cell in the body and is a necessary component in hundreds of metabolic processes. Magnesium supports muscle, immune and nerve function, and energy transport. Magnesium functions as a cofactor in many biochemical reactions. Magnesium is also a coordinating ion for adenosine triphosphate (ATP) , the main carrier of metabolic energy in the body. Magnesium is also required for biosynthetic processes such as glycolysis, formation of cyclic adenosine monophosphate (cAMP), energy-dependent membrane transport, and transmission of genetic code for protein synthesis.